Investigation of the Sensitivity of Mycobacterium Tuberculosis Strains Isolated from Various Clinical Samples in Eastern Turkey to Major Anti-tuberculosis Drugs

Objective: In the study, 419 Mycobacterium tuberculosis complex strains (MTC), which were isolated from samples sent to Regional Tuberculosis Laboratory in our city between 2015 and 2019 with suspected Erzurum surrounding cities investigated. Methods: Our research is a retrospective cross-sectional study clinical Public Health suspicion of within five-year period January December first evaluated by using Ehrlich-Ziehl-Neelsen staining technique. The then simultaneously inoculated into automated culture system (BACTEC MGIT 960) Löwenstein-Jensen medium. Sensitivity was conducted for isoniazide, rifampicin, streptomycin ethambutol antibiotics BACTEC 960 defined MTC identification test (TBc ID) reproduction positive tubes. Results: 337 (80.4%) investigated susceptible all major anti-TB drugs, while 82 (19.6%) found be resistant at least one drug. distribution resistance ratios isoniazid (11.9%), (11.7%), rifampicin (4.1%), (3.6%). Multi-drug (MDR)–TB ratio (isoniazid+ rifampicin) Conclusions: drugs investigated, highest drug determined isoniazid. lowest ethambutol.